MUTATIONS IN THE GENE CODING FOR THE M2-MUSCARINIC ACETYLCHOLINE RECEPTOR CHRM2, A POTENTIAL NEW CANDIDATE GENE FOR DILATED CARDIOMYOPATHY
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چکیده
منابع مشابه
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15 صفحه اولHeart rate recovery after maximal exercise is associated with acetylcholine receptor M2 (CHRM2) gene polymorphism.
The determinants of heart rate (HR) recovery after exercise are not well known, although attenuated HR recovery is associated with an increased risk of cardiovascular mortality. Because acetylcholine receptor subtype M2 (CHRM2) plays a key role in the cardiac chronotropic response, we tested the hypothesis that, in healthy individuals, the CHRM2 gene polymorphisms might be associated with HR re...
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متن کاملA missense mutation in the CHRM2 gene is associated with familial dilated cardiomyopathy.
Circulating autoantibodies against the M2-muscarinic acetylcholine receptor (CHRM2) have been detected in patients with dilated cardiomyopathy (DCM). However, it has yet to be determined whether the pathogenesis of familial DCM may be linked to the genetic variability of the CHRM2 gene. The coding regions of the CHRM2 gene were examined by direct DNA sequencing. Plasma concentrations of autoant...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2011
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(11)60225-8